Anti-FOXF1 Picoband® Antibody Fluoro488 Conjugated

Forkhead box protein F1 is a protein that in humans is encoded by the FOXF1 gene. It is mapped to 16q24.1. This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.

Forkhead box protein F1; Forkhead-related activator 1; FREAC-1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1; FOXF1; FKHL5; FREAC1

Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.

1. Sen, P., Thakur, N., Stockton, D. W., Langston, C., Bejjani, B. A. Expanding the phenotype of alveolar capillary dysplasia (ACD) . J. Pediat. 145: 646-651, 2004. 2. Sen, P., Yang, Y., Navarro, C., Silva, I., Szafranski, P., Kolodziejska, K. E., Dharmadhikari, A. V., Mostafa, H., Kozakewich, H., Kearney, D., Cahill, J. B., Whitt, M., and 70 others. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum. Mutat. 34: 801-811, 2013. 3. Stankiewicz, P., Sen, P., Bhatt, S. S., Storer, M., Xia, Z., Bejjani, B. A., Ou, Z., Wiszniewska, J., Driscoll, D. J., Maisenbacher, M. K., Bolivar, J., Bauer, M., and 32 others. Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations. Am. J. Hum. Genet. 84: 780-791, 2009. Note: Erratum: Am. J. Hum. Genet. 85: 537 only, 2009.