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Anti-Carbonic Anhydrase 4/CA4 Picoband® Antibody Fluoro550 Conjugated

Product Specifications

Background

Carbonic anhydrase 4 is an enzyme that in humans is encoded by the CA4 gene. It is mapped to 11; 11 C. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport.

Synonyms

Carbonic anhydrase 4; Carbonate dehydratase IV; Carbonic anhydrase IV; CA-IV; Ca4; Car4

Gene Name

Ca4

Gene ID

12351

UniProt

Q64444

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse Carbonic Anhydrase 4/CA4 recombinant protein (Position: E25-L291) .

Clonality

Polyclonal

Tissue Specificity

Expressed in the endothelium of the choriocapillaris in eyes (at protein level) . Not expressed in the retinal epithelium at detectable levels. .

Applications

Flow Cytometry

Field of Research

Neuroscience, Sensory System, Visual System

Purification

Immunogen affinity purified.

Form

Liquid

Function

Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4.

References & Citations

1. Alvarez, B. V., Vithana, E. N., Yang, Z., Koh, A. H., Yeung, K., Yong, V., Shandro, H. J., Chen, Y., Kolatkar, P., Palasingam, P., Zhang, K., Aung, T., Casey, J. R. Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa. Invest. Ophthal. Vis. Sci. 48: 3459-3468, 2007. 2. Bardien, S., Ebenezer, N., Greenberg, J., Inglehearn, C. F., Bartmann, L., Goliath, R., Beighton, P., Ramesar, R., Bhattacharya, S. S. An eighth locus for autosomal dominant retinitis pigmentosa is linked to chromosome 17q. Hum. Molec. Genet. 4: 1459-1462, 1995. 3. Bardien, S., Ramesar, R., Bhattacharya, S., Greenberg, J. Retinitis pigmentosa locus on 17q (RP17) : fine localization to 17q22 and exclusion of the PDEG and TIMP2 genes. Hum. Genet. 101: 13-17, 1997.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

35032 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Carbonic anhydrase 4

Subcellular Location

Cell membrane. GPI-anchor.

Protein Name

Carbonic anhydrase 4

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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