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Anti-SYP/Synaptophysin Antibody Picoband® (monoclonal, 3G12) Fluoro647 Conjugated

Product Specifications

Background

SYP (Synaptophysin) is located on the short arm of X chromosome (Xp11.23-p11.22) . The protein is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present inneuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has led to the use of synaptophysin immunostaining for quantification of synapses. Also, the protein binds cholesterol and is thought to targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR) .

Synonyms

MRXSYP|Major synaptic vesicle protein p38

Gene Name

SYP

Gene ID

6855

UniProt

Human (P08247), Mouse (Q62277), Rat (P07825)

Host

Mouse

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Synaptophysin, identical to the related mouse and rat sequences.

Clonality

Monoclonal

Clone

Clone: 3G12

Tissue Specificity

Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.

Applications

Flow Cytometry

Field of Research

Cell Adhesion Proteins, Epigenetics and Nuclear Signaling, Integrins, Mediator Complex, Neuroscience, Receptors, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.Involved in the regulation of short-term and long-term synaptic plasticity (By similarity) .

References & Citations

1. Calhoun ME, Jucker M, Martin LJ, Thinakaran G, Price DL, Mouton PR (December 1996) . Comparative evaluation of synaptophysin-based methods for quantification of synapses. J. Neurocytol.25 (12) : 821–8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Synaptophysin

Subcellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Protein Name

Synaptophysin

Isotype

Mouse IgG2b

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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