Anti-ATP11C Antibody Picoband® Fluoro488 Conjugated

Phospholipid-transporting ATPase IG (EC:7.6.2.1) ; ATPase IQ; ATPase class VI type 11C; P4-ATPase flippase complex alpha subunit ATP11C; ATP11C; ATPIG, ATPIQ

A synthetic peptide corresponding to a sequence in the middle region of human ATP11C, which shares 83.8% and 86.5% amino acid (aa) sequence identity with mouse and rat ATP11C, respectively.

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate PS flipping in pro-B cells. May be involved in the transport of cholestatic bile acids.

1. Arashiki, N., Takakuwa, Y., Mohandas, N., Hale, J., Yoshida, K., Ogura, H., Utsugisawa, T., Ohga, S., Miyano, S., Ogawa, S., Kojima, S., Kanno, H. ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia. Haematologica 101: 559-565, 2016. 2. Nesbit, M. A., Bowl, M. R., Harding, B., Schlessinger, D., Whyte, M. P., Thakker, R. V. X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase. Genomics 84: 1060-1070, 2004. 3. Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, T. R., Matsuda, F., Nagata, S. Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science 344: 1164-1168, 2014.