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Anti-PCTAIRE1/CDK16 Antibody Picoband®

Boster Bio Anti-PCTAIRE1/CDK16 Antibody Picoband® catalog # A06102-1. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Cyclin-dependent kinase 16 is a protein that in humans is encoded by the CDK16 gene. This gene is mapped to Xp11.3. The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

Cyclin-dependent kinase 16 (EC:2.7.11.22) ; Cell division protein kinase 16; PCTAIRE-motif protein kinase 1; Serine/threonine-protein kinase PCTAIRE-1; CDK16; PCTAIRE1; PCTK1

Gene Name

CDK16

Gene ID

5127

UniProt

Q00536

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PCTAIRE1/CDK16 recombinant protein (Position: N392-H443) .

Clonality

Polyclonal

Tissue Specificity

Detected in pancreas islets (at protein level) . Detected in brain and pancreas.

Applications

ELISA, Flow Cytometry, IHC, WB

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity) . Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro) .

References & Citations

1. Knight, J. C., Renwick, P. J., Downing, J. R., Okuda, T. Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3. Cytogenet. Cell Genet. 71: 155-157, 1995. 2. Meyerson, M., Enders, G. H., Wu, C.-L., Su, L.-K., Gorka, C., Nelson, C., Harlow, E., Tsai, L.-H. A family of human cdc2-related protein kinases. EMBO J. 11: 2909-2917, 1992. 3. Okuda, T., Cleveland, J. L., Downing, J. R. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene 7: 2249-2258, 1992.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

17828 MW

Observed Molecular Weight

56 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Cyclin dependent kinase 16

Subcellular Location

Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm. Secretory vesicle. Synaptosome.

Protein Name

Cyclin-dependent kinase 16

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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