Anti-PAR1/Thrombin Receptor/F2R Antibody Picoband® Fluoro488 Conjugated

Proteinase-activated receptor 1  (PAR1), also known as the  coagulation factor II (thrombin) receptor,   is a protein  that in humans is encoded by the  F2R  gene. By fluorescence in situ hybridization, this gene is mapped to 5q13, confirming its presence as a single locus in the human genome. PAR1 is a  G protein-coupled receptor  involved in the regulation of  thrombotic  response. Proteolytic cleavage leads to the activation of the receptor. The expression of PAR1 is both required and sufficient to promote growth and invasion of breast carcinoma cells in a xenograft mouse model.&nbsp

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

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