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Anti-PAR1/Thrombin Receptor/F2r Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Proteinase-activated receptor 1  (PAR1), also known as the  coagulation factor II (thrombin) receptor,   is a protein  that in humans is encoded by the  F2R  gene. By fluorescence in situ hybridization, this gene is mapped to 5q13, confirming its presence as a single locus in the human genome. PAR1 is a  G protein-coupled receptor  involved in the regulation of  thrombotic  response. Proteolytic cleavage leads to the activation of the receptor. The expression of PAR1 is both required and sufficient to promote growth and invasion of breast carcinoma cells in a xenograft mouse model.&nbsp

Synonyms

Proteinase-activated receptor 1; PAR-1; Thrombin receptor; F2r; Par1

Gene Name

F2r

Gene ID

25439

UniProt

P26824

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived rat PAR1/Thrombin Receptor/F2r recombinant protein (Position: R137-A432) .

Clonality

Polyclonal

Tissue Specificity

Platelets and vascular endothelial cells.

Applications

Flow Cytometry

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

References & Citations

1. Bahou, W. F., Nierman, W. C., Durkin, A. S., Potter, C. L., Demetrick, D. J. Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5. Blood 82: 1532-1537, 1993. 2. Boire, A., Covic, L., Agarwal, A., Jacques, S., Sherifi, S., Kuliopulos, A. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120: 303-131, 2005. 3. Chu, H.-W., Cheng, C.-W., Chou, W.-C., Hu, L.-Y., Wang, H.-W., Hsiung, C.-N., Hsu, H.-M., Wu, P.-E., Hou, M.-F., Shen, C.-Y., Yu, J.-C. A novel estrogen receptor-microRNA 190a-PAR-1-pathway regulates breast cancer progression, a finding initially suggested by genome-wide analysis of loci associated with lymph-node metastasis. Hum. Molec. Genet. 23: 355-367, 2014.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Coagulation factor II (thrombin) receptor

Subcellular Location

Cell membrane. Multi-pass membrane protein.

Protein Name

Proteinase-activated receptor 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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