Anti-GLUT9/SLC2A9 Antibody Picoband® Fluoro488 Conjugated

Solute carrier family 2, facilitated glucose transporter member 9, also known as SLC2A9, is a protein that in humans is encoded by the SLC2A9 gene. This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. This gene is mapped to 4p16.1. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. This gene transports urate and fructose. It may have a role in the urate reabsorption by proximal tubules. This gene also transports glucose at low rate.

Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level) .

1. Chiba, T., Matsuo, H., Nagamori, S., Nakayama, A., Kawamura, Y., Shimizu, S., Sakiyama, M., Hosoyamada, M., Kawai, S., Okada, R., Hamajima, N., Kanai, Y., Shinomiya, N. Identification of a hypouricemia patient with SLC2A9 R380W, a pathogenic mutation for renal hypouricemia type 2. Nucleosides Nucleotides Nucleic Acids 33: 261-265, 2014. 2. Dinour, D., Gray, N. K., Campbell, S., Shu, X., Sawyer, L., Richardson, W., Rechavi, G., Amariglio, N., Ganon, L., Sela, B.-A., Bahat, H., Goldman, M., Weissgarten, J., Millar, M. R., Wright, A. F., Holtzman, E. J. Homozygous SLC2A9 mutations cause severe renal hypouricemia. J. Am. Soc. Nephrol. 21: 64-72, 2010. 3. Dinour, D., Gray, N. K., Ganon, L., Knox, A. J. S., Shalev, H., Sela, B.-A., Campbell, S., Sawyer, L., Shu, X., Valsamidou, E., Landau, D., Wright, A. F., Holtzman, E. J. Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2. Nephrol. Dial. Transplant. 27: 1035-1041, 2012.

Basolateral cell membrane. Multi-pass membrane protein. Plasma membrane. Apical cell membrane. Multi-pass membrane protein. Basolateral cell membrane. Multi-pass membrane protein.