Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-CD79b Antibody Picoband® (monoclonal, 6H11) Fluoro647 Conjugated

Product Specifications

Background

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene. By fluorescence in situ hybridization, It is mapped to 17q23.3. The CD79B protein together with the related CD79A protein, forms a dimer associated with membrane bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR) which is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig) . CD79b also can enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Synonyms

B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD79b; CD79B; B29, IGB

Gene Name

CD79B

Gene ID

974

UniProt

P40259

Host

Mouse

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human CD79b recombinant protein (Position: A29-E229) . Human CD79b shares 70% amino acid (aa) sequence identity with mouse CD79b.

Clonality

Monoclonal

Clone

Clone: 6H11

Tissue Specificity

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

Applications

Flow Cytometry

Field of Research

DNA/RNA, DNA Damage & Repair, DNA Damage Response, DNA Synthesis, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6) -mediated barrier protection.

References & Citations

1. Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta 2. Dobbs, A. K., Yang, T., Farmer, D., Kager, L., Parolini, O., Conley, M. E. Cutting edge: a hypomorphic mutation in Ig-beta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development. J. Immun. 179: 2055-2059, 2007. 3. Wood, W. J., Jr., Thompson, A. A., Korenberg, J., Chen, X., May, W., Wall, R., Denny, C. T. Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB) . Genomics 16: 187-192, 1993.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

B-cell antigen receptor complex-associated protein beta chain

Subcellular Location

Nucleolus. Perinuclear region.

Protein Name

CD79b molecule

Isotype

Mouse IgG1

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

TRIT1 Antibody
A67606-50UG 50 µg

TRIT1 Antibody

Sign In for Pricing
View Details
SNX11 Protein Vector (Rat) (pPM-C-HA)
45021027 500 ng

SNX11 Protein Vector (Rat) (pPM-C-HA)

Sign In for Pricing
View Details
Box of 100 Slow Qualitative Filter, 45 Mm
QL04A0045C Box of 100

Box of 100 Slow Qualitative Filter, 45 Mm

Sign In for Pricing
View Details
Tmtc2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)
K6667407 1.0 µg DNA

Tmtc2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

Sign In for Pricing
View Details
Bromo-PEG5-phosphonic acid diethyl ester
MF-0032493-01 100 mg

Bromo-PEG5-phosphonic acid diethyl ester

Sign In for Pricing
View Details
Bromo-PEG5-phosphonic acid diethyl ester
MF-0032493-02 500 mg

Bromo-PEG5-phosphonic acid diethyl ester

Sign In for Pricing
View Details