Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-ATF1 Antibody Picoband® (monoclonal, 7F8) Fluoro488 Conjugated

Product Specifications

Background

ATF1, also known as activating transcription factor 1, is a protein that in humans is encoded by the ATF1 gene. It is mapped to 12q13.12. This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3) . Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.

Synonyms

Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; Protein TREB36; ATF1

Gene Name

ATF1

Gene ID

466

UniProt

P18846

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ATF1 recombinant protein (Position: M1-V271) . Human ATF1 shares 91% amino acid (aa) sequence identity with mouse ATF1.

Clonality

Monoclonal

Clone

Clone: 7F8

Tissue Specificity

B-lymphocytes.

Applications

Flow Cytometry

Field of Research

Actin Binding Proteins, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

References & Citations

1. ucman, J., Delattre, O., Desmaze, C., Epstein, A. L., Stenman, G., Speleman, F., Fletchers, C. D. M., Aurias, A., Thomas, G. EWS and ATF-1 gene fusion induced by t (12;22) translocation in malignant melanoma of soft parts. Nature Genet. 4: 341-345, 1993. 2. Entrez Gene: ATF1 activating transcription factor 1

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Cyclic AMP-dependent transcription factor ATF-1

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Protein Name

Activating transcription factor 1

Isotype

Mouse IgG2a

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

Frozen Tissue Sections, Kidney
CS614001 5x 5 µm

Frozen Tissue Sections, Kidney

Sign In for Pricing
View Details
Lentiviral mouse Setd6 shRNA (UAS) - Lentiviral mouse Setd6 shRNA (UAS) (100)
GTR15293757 1 Vial

Lentiviral mouse Setd6 shRNA (UAS) - Lentiviral mouse Setd6 shRNA (UAS) (100)

Sign In for Pricing
View Details
Polyclonal MIF Antibody
APR00295G 0.1mg

Polyclonal MIF Antibody

Sign In for Pricing
View Details
Anti-DENV NS3
Y030102 100 µL

Anti-DENV NS3

Sign In for Pricing
View Details
Rabbit Monoclonal ABAT Antibody (5B6)
NBP3-26537-100ul 100 µL

Rabbit Monoclonal ABAT Antibody (5B6)

Sign In for Pricing
View Details
Human Activin B ELISA Kit
MBS099404-01 48 Well

Human Activin B ELISA Kit

Sign In for Pricing
View Details