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Anti-Neurofibromin/NF1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Neurofibromin 1 (NF1) is a gene in humans that is located on chromosome 17. This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

Synonyms

Neurofibromin; Neurofibromatosis-related protein NF-1; Neurofibromin truncated; NF1

Gene Name

NF1

Gene ID

4763

UniProt

P21359

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Neurofibromin/NF1 recombinant protein (Position: R160-Q270) .

Clonality

Polyclonal

Tissue Specificity

Detected in brain, peripheral nerve, lung, colon and muscle.

Applications

Flow Cytometry

Field of Research

Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes, Proteolysis/Ubiquitin, Proteolytic Enzymes

Purification

Immunogen affinity purified.

Form

Liquid

Function

Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.

References & Citations

1. Scheffzek K, Welti S (2012) . Neurofibromin: Protein Domains and Functional Characteristics. In Upadhyaya M, Cooper D (eds.) . Neurofibromatosis Type 1. Berlin, Heidelberg: Springer. pp. 305–326. 2. Trovó-Marqui AB, Tajara EH (July 2006) . Neurofibromin: a general outlook. Clinical Genetics. 70 (1) : 1–13. 3. Peltonen S, Pöyhönen M (2012) . Clinical Diagnosis and Atypical Forms of NF1. In Upadhyaya M, Cooper D (eds.) . Neurofibromatosis Type 1. Berlin, Heidelberg: Springer. pp. 17–30.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Neurofibromin 1

Subcellular Location

Cytoplasm.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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