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Anti-Fascin 2/FSCN2 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

A07840-2-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Fascin-2 is a protein that in humans is encoded by the FSCN2 gene. It is mapped to 17q25.3. This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Fascin-2; Retinal fascin; FSCN2

Gene Name

FSCN2

Gene ID

25794

UniProt

O14926

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Fascin 2/FSCN2 recombinant protein (Position: M1-K167) .

Clonality

Polyclonal

Tissue Specificity

Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.

Applications

Flow Cytometry

Field of Research

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

References & Citations

1. Hillier LD, Lennon G, Becker M, et al. (1997) . Generation and analysis of 280,000 human expressed sequence tags. Genome Res. 6 (9) : 807–28. 2. Tubb BE, Bardien-Kruger S, Kashork CD, et al. (2000) . Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. Genomics. 65 (2) : 146–56. 3. Saishin Y, Ishikawa R, Ugawa S, et al. (2000) . Retinal fascin: functional nature, subcellular distribution, and chromosomal localization. Invest. Ophthalmol. Vis. Sci. 41 (8) : 2087–95.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

49229 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Fascin actin-bundling protein 2, retinal

Subcellular Location

Nucleus.

Protein Name

Chromaffin granule amine transporter

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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