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Anti-CPT2/CPT1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Carnitine O-palmitoyltransferase 2, mitochondrial is an enzyme that in humans is encoded by the CPT2 gene. It is mapped to 1p32.3. The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders.

Synonyms

Carnitine O-palmitoyltransferase 2, mitochondrial; Carnitine palmitoyltransferase II; CPT II; CPT2; CPT1

Gene Name

CPT2

Gene ID

1376

UniProt

P23786

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human CPT2/CPT1 recombinant protein (Position: Q33-D646) .

Clonality

Polyclonal

Tissue Specificity

Expressed mainly in adipose tissues.

Applications

Flow Cytometry

Field of Research

Cardiovascular, G Protein Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

References & Citations

1. Bonnefont JP, Demaugre F, Prip-Buus C, Saudubray JM, Brivet M, Abadi N, Thuillier L (2000) . Carnitine palmitoyltransferase deficiencies. Mol. Genet. Metab. 68 (4) : 424–440. 2. van der Leij FR, Huijkman NC, Boomsma C, Kuipers JR, Bartelds B (2000) . Genomics of the human carnitine acyltransferase genes. Mol. Genet. Metab. 71 (1–2) : 139–153. 3. Sigauke E, Rakheja D, Kitson K, Bennett MJ (2003) . Carnitine palmitoyltransferase II deficiency: a clinical, biochemical, and molecular review. Lab. Invest. 83 (11) : 1543–1554.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

51990 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Carnitine palmitoyltransferase 2

Subcellular Location

Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side

Protein Name

Angiotensinogen

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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