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Anti-beta 2 Microglobulin/B2m Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Beta-2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells (excludes red blood cells) . In humans, the beta-2-microglobulin protein is encoded by the B2M gene. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

Synonyms

Beta-2-microglobulin; B2m

Gene Name

B2m

Gene ID

12010

UniProt

P01887

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived rat beta 2 Microglobulin/B2m recombinant protein (Position: I21-M119) .

Clonality

Polyclonal

Tissue Specificity

Detected in lung, spleen, uterus, vagina and epididymis. .

Applications

Flow Cytometry

Field of Research

Immunoglobulins, Immunology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Component of the class I major histocompatibility complex (MHC) . Involved in the presentation of peptide antigens to the immune system.

References & Citations

1. Güssow D, Rein R, Ginjaar I, Hochstenbach F, Seemann G, Kottman A, Ploegh HL (1 November 1987) . The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. J. Immunol. 139 (9) : 3132–8. 2. Munshi NC, Longo DL, Anderson KC (2011) . Chapter 111: Plasma Cell Disorders. In Loscalzo J, Longo DL, Fauci AS, Dennis LK, Hauser SL. Harrison's Principles of Internal Medicine (18th ed.) . McGraw-Hill Professional. pp. 936–44. 3. Pignone M, Nicoll D; McPhee SJ (2004) . Pocket guide to diagnostic tests (4th ed.) . New York: McGraw-Hill. p. 191.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

22875 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Beta-2 microglobulin

Subcellular Location

Secreted . Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.

Protein Name

Neutrophil gelatinase-associated lipocalin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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