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Anti-IL32 Antibody (monoclonal, 2I2) Fluoro647 Conjugated

Product Specifications

Background

Interleukin 32 (Il32) is a protein that in humans is encoded by the IL32 gene. This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Synonyms

Interleukin-32; IL-32; Natural killer cells protein 4; Tumor necrosis factor alpha-inducing factor; IL32; NK4; TAIF

Gene Name

IL32

Gene ID

9235

UniProt

P24001

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human IL32 recombinant protein (Position: A31-K234) .

Clonality

Monoclonal

Clone

Clone: 2I2

Tissue Specificity

Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.

Applications

Flow Cytometry

Field of Research

ER Proteins, Immunology, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.

References & Citations

1. Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA (January 2005) . Interleukin-32: a cytokine and inducer of TNFalpha. Immunity. 22 (1) : 131–42. 2. Mabilleau G, Sabokbar A (2009) . Interleukin-32 promotes osteoclast differentiation but not osteoclast activation. PLoS ONE. 4 (1) : e4173.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin 32

Subcellular Location

Secreted

Protein Name

High mobility group protein B3

Isotype

Mouse IgG2b

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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