Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-DCK Antibody Picoband® (monoclonal, 3G10) Fluoro647 Conjugated

Selected Variant

M01655-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Deoxycytidine kinase (dCK) is an enzyme which is encoded by the DCK gene in humans. Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.

Synonyms

Deoxycytidine kinase; dCK; DCK

Gene Name

DCK

Gene ID

1633

UniProt

P27707

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human DCK recombinant protein (Position: E17-L260) .

Clonality

Monoclonal

Clone

Clone: 3G10

Tissue Specificity

Expressed ubiquitously in normal tissues.

Applications

Flow Cytometry

Field of Research

Actin Binding Proteins, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) . Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

References & Citations

1. Chottiner, E. G., Shewach, D. S., Datta, N. S., Ashcraft, E., Gribbin, D., Ginsburg, D., Fox, I. H., Mitchell, B. S. Cloning and expression of human deoxycytidine kinase cDNA. Proc. Nat. Acad. Sci. 88: 1531-1535, 1991. 2. Stegmann, A. P. A., Honders, M. W., Bolk, M. W. J., Wessels, J., Willemze, R., Landegent, J. E.Assignment of the human deoxycytidine kinase (DCK) gene to chromosome 4 band q13.3-q21.1. Genomics 17: 528-529, 1993.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Deoxycytidine kinase

Subcellular Location

Nucleus

Protein Name

Activating transcription factor 1

Isotype

Mouse IgG2b

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Anti-HDAC11 Antibody Picoband® (PE Conjugate)
PB9630-PE 100 µg/Vial

Anti-HDAC11 Antibody Picoband® (PE Conjugate)

Sign In for Pricing
View Details
Anti-ABCB4 Antibody Picoband®, Dylight550 Conjugate
PA2090-Dylight550 100 µg

Anti-ABCB4 Antibody Picoband®, Dylight550 Conjugate

Sign In for Pricing
View Details
CD45RO (UCHL-1), CF488A conjugate, 0.1mg/mL
BNC880003-100 1x 100 µL

CD45RO (UCHL-1), CF488A conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Anti-HELLS Antibody Picoband®
A04702-1 100 µg/Vial

Anti-HELLS Antibody Picoband®

Sign In for Pricing
View Details
Anti-RND1 Antibody Picoband®
A06347 100 µg/Vial

Anti-RND1 Antibody Picoband®

Sign In for Pricing
View Details
Anti-IRF5 Rabbit Monoclonal Antibody, Carrier-free
M00958-carrier-free 100 µL

Anti-IRF5 Rabbit Monoclonal Antibody, Carrier-free

Sign In for Pricing
View Details