Anti-MVP Antibody Picoband® (monoclonal, 8B12) Fluoro488 Conjugated
Product Specifications
Background
Major vault protein is a protein that in humans is encoded by the MVP gene. This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Synonyms
Major vault protein; MVP; Lung resistance-related protein; MVP; LRP
Gene Name
MVP
Gene ID
9961
UniProt
Q14764
Host
Mouse
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MVP recombinant protein (Position: A2-H259) .
Clonality
Monoclonal
Clone
Clone: 8B12
Tissue Specificity
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Applications
Flow Cytometry
Field of Research
Cardiogenesis, Cardiovascular,2339, DNA/RNA, Epigenetics and Nuclear Signaling, Transcription Factors/Regulators
Purification
Immunogen affinity purified.
Form
Liquid
Function
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
References & Citations
1. Entrez Gene: MVP major vault protein. 2. Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ (Jun 1996) . Major vault protein LRP-related multidrug resistance. European Journal of Cancer. 32A (6) : 979–84.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Major vault protein
Subcellular Location
Nuclear pore complex; Cytoplasm; perinuclear region
Isotype
Mouse IgG2a
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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