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Anti-MVP Antibody Picoband® (monoclonal, 8B12)

Boster Bio Anti-MVP Antibody Picoband® (monoclonal, 8B12) catalog # M00642-1. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Major vault protein is a protein that in humans is encoded by the MVP gene. This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.

Synonyms

Major vault protein; MVP; Lung resistance-related protein; MVP; LRP

Gene Name

MVP

Gene ID

9961

UniProt

Q14764

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human MVP recombinant protein (Position: A2-H259) .

Clonality

Monoclonal

Clone

Clone: 8B12

Tissue Specificity

Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Cardiogenesis, Cardiovascular,2339, DNA/RNA, Epigenetics and Nuclear Signaling, Transcription Factors/Regulators

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500μg/ml.

Function

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

References & Citations

1. Entrez Gene: MVP major vault protein. 2. Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ (Jun 1996) . Major vault protein LRP-related multidrug resistance. European Journal of Cancer. 32A (6) : 979–84.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

100-110 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Major vault protein

Subcellular Location

Nuclear pore complex; Cytoplasm; perinuclear region

Isotype

Mouse IgG2a

Contents

243

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