Anti-MTR Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Methionine synthase also known as MS, MeSe, MetH is responsible for the regeneration of methionine from homocysteine. In humans it is encoded by the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase) . It is mapped to 1q43. This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms
Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Vitamin-B12 dependent methionine synthase; MS; MTR
Gene Name
MTR
Gene ID
4548
UniProt
Q99707
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MTR recombinant protein (Position: V880-D1095) .
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta. Expressed at lower levels in lung, liver and kidney.
Applications
Flow Cytometry
Field of Research
Mesenchymal Stem Cells, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob (I) alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) .
References & Citations
1.MTR 5-methyltetrahydrofolate-homocysteine methyltransferase (Homo sapiens) . Entrez. 19 May 2009. Retrieved 24 May 2009. 2. Li YN, Gulati S, Baker PJ, Brody LC, Banerjee R, Kruger WD (December 1996) . Cloning, mapping and RNA analysis of the human methionine synthase gene. Human Molecular Genetics. 5 (12) : 1851–8. 3. Banerjee RV, Matthews RG (March 1990) . Cobalamin-dependent methionine synthase. FASEB Journal. 4 (5) : 1450–9.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
47643 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
5-methyltetrahydrofolate-homocysteine methyltransferase
Subcellular Location
Lysosome.
Protein Name
Alpha-galactosidase A
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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