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Anti-MTR Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Methionine synthase also known as MS, MeSe, MetH is responsible for the regeneration of methionine from homocysteine. In humans it is encoded by the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase) . It is mapped to 1q43. This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Synonyms

Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Vitamin-B12 dependent methionine synthase; MS; MTR

Gene Name

MTR

Gene ID

4548

UniProt

Q99707

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human MTR recombinant protein (Position: V880-D1095) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta. Expressed at lower levels in lung, liver and kidney.

Applications

Flow Cytometry

Field of Research

Mesenchymal Stem Cells, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob (I) alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) .

References & Citations

1.MTR 5-methyltetrahydrofolate-homocysteine methyltransferase (Homo sapiens) . Entrez. 19 May 2009. Retrieved 24 May 2009. 2. Li YN, Gulati S, Baker PJ, Brody LC, Banerjee R, Kruger WD (December 1996) . Cloning, mapping and RNA analysis of the human methionine synthase gene. Human Molecular Genetics. 5 (12) : 1851–8. 3. Banerjee RV, Matthews RG (March 1990) . Cobalamin-dependent methionine synthase. FASEB Journal. 4 (5) : 1450–9.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

47643 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

5-methyltetrahydrofolate-homocysteine methyltransferase

Subcellular Location

Lysosome.

Protein Name

Alpha-galactosidase A

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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