Anti-Histone H1.0/H1F0 Antibody Picoband® Fluoro594 Conjugated

H1 histone family, member 0?is a member of the?histone?family of nuclear?proteins?which are a component of?chromatin. In humans, this protein is encoded by the?H1F0?gene. It is mapped to 22q13.1. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family.

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

1. Doenecke D, Tönjes R (February 1986) . Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene. Journal of Molecular Biology. 187 (3) : 461–4. 2. Albig W, Drabent B, Kunz J, Kalff-Suske M, Grzeschik KH, Doenecke D (June 1993) . All known human H1 histone genes except the H1 (0) gene are clustered on chromosome 6. Genomics. 16 (3) : 649–54.