Anti-Dopamine beta Hydroxylase/DBH Antibody Picoband® Fluoro488 Conjugated

Dopamine beta-hydroxylase  (DBH), also known as  dopamine beta-monooxygenase, is an  enzyme  (EC1.14.17.1) that in humans is encoded by the DBH  gene. Dopamine beta-hydroxylase  catalyzes  the  chemical reaction. It is mapped to 9q34.2. The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.

Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]) . Also detected in macrophages mycobacterial granulomas. Expressed in group2 innate lymphoid cells (ILC2s) during lung disease.

1. Rush RA, Geffen LB (1980) . Dopamine beta-hydroxylase in health and disease. Critical Reviews in Clinical Laboratory Sciences. 12 (3) : 241–77. 2. Kaufman S, Bridgers WF, Baron J (1968) . The Mechanism of Action of Dopamine beta-Hydroxylase. Advances in Chemistry. 77, chapter 73: 172–176. 3. Friedman S, Kaufman S (May 1966) . An electron paramagnetic resonance study of 3,4-dihydroxyphenylethylamine beta-hydroxylase. The Journal of Biological Chemistry. 241 (10) : 2256–9.