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Anti-Apolipoprotein L1/APOL1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Apolipoprotein L1 is a protein that in humans is encoded by the APOL1 gene. It is mapped to 22q12.3. This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.

Synonyms

Apolipoprotein L1; Apolipoprotein L; Apo-L; ApoL; Apolipoprotein L-I; ApoL-I; APOL1; APOL

Gene Name

APOL1

Gene ID

8542

UniProt

O14791

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Apolipoprotein L1/APOL1 recombinant protein (Position: M228-L398) .

Clonality

Polyclonal

Tissue Specificity

Plasma. Found on APOA-I-containing high density lipoprotein (HDL3) . Expressed in pancreas, lung, prostate, liver, placenta and spleen.

Applications

Flow Cytometry

Field of Research

Cardiogenesis, Cardiovascular, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors, Transcription Factors/Regulators

Purification

Immunogen affinity purified.

Form

Liquid

Function

May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.

References & Citations

1. Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001) . The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. Genomics. 74 (1) : 71–8. 2. Pérez-Morga D, Vanhollebeke B, Paturiaux-Hanocq F, Nolan DP, Lins L, Homblé F, Vanhamme L, Tebabi P, Pays A, Poelvoorde P, Jacquet A, Brasseur R, Pays E (July 2005) . Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. Science. 309 (5733) : 469–72. 3. Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (April 2002) . The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue. Genomics. 79 (4) : 539–46.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Apolipoprotein L1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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