Anti-PTBP2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene. It is mapped to 1p21.3. The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants.
Synonyms
Polypyrimidine tract-binding protein 2; Neural polypyrimidine tract-binding protein; Neurally-enriched homolog of PTB; PTB-like protein; PTBP2; NPTB; PTB; PTBLP
Gene Name
PTBP2
Gene ID
58155
UniProt
Q9UKA9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PTBP2 recombinant protein (Position: M1-A504) .
Clonality
Polyclonal
Tissue Specificity
Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues.
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cardiovascular, Cytokines, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.
References & Citations
1. Makeyev, E. V., Zhang, J., Carrasco, M. A., Maniatis, T. The microRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Molec. Cell 27: 435-448, 2007. 2. Rahman, L., Bliskovski, V., Kaye, F. J., Zajac-Kaye, M. Evolutionary conservation of a 2-kb intronic sequence flanking a tissue-specific alternative exon in the PTBP2 gene. Genomics 83: 76-84, 2004.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
25847 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Polypyrimidine tract binding protein 2
Subcellular Location
Nucleus.
Protein Name
Uncharacterized protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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