Anti-MTTP Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene. It is mapped to 4q23. MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
Synonyms
Microsomal triglyceride transfer protein large subunit; MTTP; MTP
Gene Name
MTTP
Gene ID
4547
UniProt
P55157
Host
Rabbit
Reactivity
Human, Monkey, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MTTP recombinant protein (Position: N29-R702) .
Clonality
Polyclonal
Tissue Specificity
Liver and small intestine. Also found in ovary, testis and kidney.
Applications
Flow Cytometry
Field of Research
Organelles, Subcellular Markers, Tags & Cell Markers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.
References & Citations
1. Al-Shali, K., Wang, J., Rosen, F., Hegele, R. A. Ileal adenocarcinoma in a mild phenotype of abetalipoproteinemia. Clin. Genet. 63: 135-138, 2003. 2. Benayoun, L., Granot, E., Rizel, L., Allon-Shalev, S., Behar, D. M., Ben-Yosef, T. Abetalipoproteinemia in Israel: evidence for a founder mutation in the Ashkenazi Jewish population and a contiguous gene deletion in an Arab patient. Molec. Genet. Metab. 90: 453-457, 2007.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Microsomal triglyceride transfer protein
Subcellular Location
Endoplasmic reticulum.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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