Anti-ABCB5 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene.It is mapped to 7p21.1. ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules.
Synonyms
ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5; ABCB5
Gene Name
ABCB5
Gene ID
340273
UniProt
Q2M3G0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ABCB5 recombinant protein (Position: M1-D176) .
Clonality
Polyclonal
Tissue Specificity
Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level) . Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.
Applications
Flow Cytometry
Field of Research
Cancer, Drug Metabolism, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Tumor Biomarkers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.
References & Citations
1. Chen, K. G., Szakacs, G., Annereau, J.-P., Rouzaud, F., Liang, X.-J., Valencia, J. C., Nagineni, C. N., Hooks, J. J., Hearing, V. J., Gottesman, M. M. Principal expression of two mRNA isoforms (ABCB5-alpha and ABCB5-beta) of the ATP-binding cassette transporter gene ABCB5 in melanoma cells and melanocytes. Pigment Cell Res. 18: 102-112, 2005. 2. Frank, N. Y., Margaryan, A., Huang, Y., Schatton, T., Waaga-Gasser, A. M., Gasser, M., Sayegh, M. H., Sadee, W., Frank, M. H. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res. 65: 4320-4333, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
36020 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
ATP binding cassette subfamily B member 5
Subcellular Location
Cell membrane. Multi-pass membrane protein.
Protein Name
Aldo-keto reductase family 1 member B10
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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