Anti-PPCS Antibody Picoband® (monoclonal, 7G13) Fluoro488 Conjugated
Product Specifications
Background
Phosphopantothenoylcysteine synthetase in humans is encoded by the PPCS gene. Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS, one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine. By genomic sequence analysis, this PPCS gene ia mapped to chromosome 1.
Synonyms
Phosphopantothenate--cysteine ligase; Phosphopantothenoylcysteine synthetase; PPC synthetase
Gene Name
PPCS
Gene ID
79717
UniProt
Q9HAB8
Host
Mouse
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human PPCS, which shares 73.9% and 78.2% amino acid (aa) sequence identity with mouse and rat PPCS, respectively.
Clonality
Monoclonal
Clone
Clone: 7G13
Applications
Flow Cytometry
Field of Research
Cell Adhesion Proteins, Epigenetics and Nuclear Signaling, Integrins, Mediator Complex, Neuroscience, Receptors, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine.
References & Citations
1. Daugherty, M., Polanuyer, B., Farrell, M., Scholle, M., Lykidis, A., de Crecy-Lagard, V., Osterman, A. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. J. Biol. Chem. 277: 21431-21439, 2002. 2. McHugh T, Laforce R, Gallagher P, Quinn S, Diggle P, Buchanan L (2006) . Natural history of the long-term cognitive, affective, and physical sequelae of a minor traumatic brain injury. Brain and Cognition. 60 (2) : 209–11. 3. Bigler ED (2008) . Neuropsychology and clinical neuroscience of persistent post-concussive syndrome. Journal of the International Neuropsychological Society.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Phosphopantothenoylcysteine synthetase
Subcellular Location
Cytosol.
Isotype
Mouse IgG2a
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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