Anti-ADK Antibody Picoband® (monoclonal, 7F4) Fluoro647 Conjugated
Product Specifications
Background
This gene is an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
Adenosine kinase; AK; Adenosine 5'-phosphotransferase; ADK
Gene Name
ADK
Gene ID
132
UniProt
P55263
Host
Mouse
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human ADK recombinant protein (Position: K165-T351) . Human ADK shares 88.8% and 88.2% amino acid (aa) sequence identity with mouse and rat ADK, respectively.
Clonality
Monoclonal
Clone
Clone: 7F4
Tissue Specificity
Widely expressed. Highest level in placenta, liver, muscle and kidney.
Applications
Flow Cytometry
Field of Research
DNA/RNA, Epigenetics and Nuclear Signaling, Ribosome, RNA Processing, Translation
Purification
Immunogen affinity purified.
Form
Liquid
Function
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
References & Citations
1. Boison D, Scheurer L, Zumsteg V, Rulicke T, Litynski P, Fowler B, Brandner S, Mohler H: Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Proc Natl Acad Sci U S A 2002, 99: 6985-6990. 2. Fox IH, Kelley WN: The role of adenosine and 2'-deoxyadenosine in mammalian cells. Annu Rev Biochem 1978, 47: 655-686.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Adenosine kinase
Subcellular Location
Nucleus. Cytoplasm.
Protein Name
Mitofusin-1
Isotype
Mouse IgG1
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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