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Anti-Semaphorin 3B/SEMA3B Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Semaphorin-3B is a protein that in humans is encoded by the SEMA3B gene. It is mapped to 3p21.31. The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.

Synonyms

Semaphorin-3B; Sema A (V) ; Semaphorin-V; Sema V; SEMA3B; SEMA5; SEMAA

Gene Name

SEMA3B

Gene ID

7869

UniProt

Q13214

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Semaphorin 3B/SEMA3B recombinant protein (Position: Y55-R624) .

Clonality

Polyclonal

Tissue Specificity

Expressed abundantly but differentially in a variety of neural and nonneural tissues.

Applications

Flow Cytometry

Field of Research

Adapters, Coat Proteins, Cytoplasmic, Protein Trafficking, Signal Transduction, Vesicle Transport

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

References & Citations

1. Ochi K, Mori T, Toyama Y, Nakamura Y, Arakawa H (2002) . Identification of semaphorin3B as a target of p53. Neoplasia. 4 (1) : 82–7. 2. Tse C, Xiang RH, Bracht T, Naylor SL (January 2002) . Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. Cancer Research. 62 (2) : 542–6.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

104553 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Semaphorin 3B

Subcellular Location

Endoplasmic reticulum. Secreted.

Protein Name

AP-2 complex subunit beta

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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