Anti-BHC80/PHF21A Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene. The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535) /histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) .
Synonyms
PHD finger protein 21A; BHC80a; BRAF35-HDAC complex protein BHC80; PHF21A; BHC80; KIAA1696; BM-006
Gene Name
PHF21A
Gene ID
51317
UniProt
Q96BD5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human BHC80/PHF21A recombinant protein (Position: M1-Q97) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in brain. Expressed at much lower level in other tissues.
Applications
Flow Cytometry
Field of Research
Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
References & Citations
1. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000) . Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7 (6) : 347–55. 2. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (Sep 2004) . Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression. Biochem. Biophys. Res. Commun. 322 (2) : 601–8.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
PHD finger protein 21A
Subcellular Location
Nucleus.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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