Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-BHC80/PHF21A Antibody Picoband®

Boster Bio Anti-BHC80/PHF21A Antibody catalog # A08507-1. Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene. The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535) /histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) .

Synonyms

PHD finger protein 21A; BHC80a; BRAF35-HDAC complex protein BHC80; PHF21A; BHC80; KIAA1696; BM-006

Gene Name

PHF21A

Gene ID

51317

UniProt

Q96BD5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human BHC80/PHF21A recombinant protein (Position: M1-Q97) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in brain. Expressed at much lower level in other tissues.

Applications

ELISA, Flow Cytometry, IF, IHC, WB

Field of Research

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.

References & Citations

1. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000) . Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7 (6) : 347–55. 2. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (Sep 2004) . Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression. Biochem. Biophys. Res. Commun. 322 (2) : 601–8.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

75-95 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

PHD finger protein 21A

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

PI3Kδ-IN-20
HY-158147 1 Each

PI3Kδ-IN-20

Sign In for Pricing
View Details
Rat Procollagen III N-Terminal Propeptide (PIIINP) ELISA Kit
JL15692-01 48 Tests

Rat Procollagen III N-Terminal Propeptide (PIIINP) ELISA Kit

Sign In for Pricing
View Details
Rat Procollagen III N-Terminal Propeptide (PIIINP) ELISA Kit
JL15692-02 96 Tests

Rat Procollagen III N-Terminal Propeptide (PIIINP) ELISA Kit

Sign In for Pricing
View Details
CYBRD1 shRNA Plasmid (h)
sc-94877-SH 20 µg

CYBRD1 shRNA Plasmid (h)

Sign In for Pricing
View Details
Ffar2 3'UTR GFP Stable Cell Line
TU156518 1.0 mL

Ffar2 3'UTR GFP Stable Cell Line

Sign In for Pricing
View Details
AIDA Polyclonal Antibody
E55A02729 100 µg

AIDA Polyclonal Antibody

Sign In for Pricing
View Details