Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-OLFM4 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Olfactomedin 4 is a protein that in humans is encoded by the OLFM4 gene. This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion.

Synonyms

Olfactomedin-4; OLM4; Antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein; hGC-1; hOLfD; OLFM4; GW112; UNQ362; PRO698

Gene Name

OLFM4

Gene ID

10562

UniProt

Q6UX06

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human OLFM4 recombinant protein (Position: D91-Q510) .

Clonality

Polyclonal

Tissue Specificity

Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level) . Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.

Applications

Flow Cytometry

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.

References & Citations

1. Dassen H, Punyadeera C, Delvoux B, Schulkens I, Marchetti C, Kamps R, Klomp J, Dijcks F, de Goeij A, D'Hooghe T, Kyama C, Ederveen A, Dunselman G, Groothuis P, Romano A (2010) . Olfactomedin-4 regulation by estrogen in the human endometrium requires epidermal growth factor signaling. Am. J. Pathol. 177 (5) : 2495–508. 2. van der Flier LG, Haegebarth A, Stange DE, van de Wetering M, Clevers H (2009) . OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.Gastroenterology. 137 (1) : 15–7.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

211344 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Olfactomedin 4

Subcellular Location

Extracellular space. Mitochondrion.

Protein Name

Chromodomain-helicase-DNA-binding protein 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

CSH2 Antibody
A18291-100UG 100 µg

CSH2 Antibody

Ask
View Details
RPL7 Antibody
MBS8514443-01 0.1 mg

RPL7 Antibody

Ask
View Details
RPL7 Antibody
MBS8514443-02 0.1 mL (AF635)

RPL7 Antibody

Ask
View Details
RPL7 Antibody
MBS8514443-03 0.1 mL (AF610)

RPL7 Antibody

Ask
View Details
RPL7 Antibody
MBS8514443-04 0.1 mL (AF405S)

RPL7 Antibody

Ask
View Details
RPL7 Antibody
MBS8514443-05 0.1 mL (AF405L)

RPL7 Antibody

Ask
View Details