Anti-Loricrin/LOR Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Loricrin is a protein that in humans is encoded by the LOR gene. It is mapped to 1q21.3. Loricrin is a major protein component of the cornified cell envelope found in terminally differentiatedepidermal cells. It is expressed in the granular layer of all keratinized epithelial cells of mammals tested including oral, esophageal and stomach mucosa of rodents, tracheal squamous metaplasia of vitamin A deficient hamster and estrogen induced squamous vaginal epithelium of rats.
Synonyms
Loricrin; LOR; LRN
Gene Name
LOR
Gene ID
4014
UniProt
P23490
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Loricrin/LOR recombinant protein (Position: M1-K312) .
Clonality
Polyclonal
Tissue Specificity
Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.
Applications
Flow Cytometry
Field of Research
Cell Biology, Cytokines, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Interferons, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin & Ubiquitin Like Modifiers, Ubiquitin E3 Enzymes
Purification
Immunogen affinity purified.
Form
Liquid
Function
Major keratinocyte cell envelope protein.
References & Citations
1. Hohl D, Mehrel T, Lichti U, Turner ML, Roop DR, Steinert PM (May 1991) . Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins. J Biol Chem. 266 (10) : 6626–36. 2. Yoneda K, Hohl D, McBride OW, Wang M, Cehrs KU, Idler WW, Steinert PM (Oct 1992) . The human loricrin gene. J Biol Chem. 267 (25) : 18060–6.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39411 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Loricrin
Subcellular Location
Nucleoplasm. Cytoplasm.
Protein Name
Zinc finger protein Helios
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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