Anti-LMTK3 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Lemur tyrosine kinase 3 is a protein that in humans is encoded by the LMTK3 gene. It is mapped to 19q13.33. LMTK3 (lemur tyrosine kinase 3), also known as LMR3 or TYKLM3, is a 1,460 amino acid protein that contains one protein kinase domain. One of several members of the protein kinase superfamily, LMTK3 is expressed at low levels in brain and testis where it catalyzes the ATP-dependent phosphorylation of target proteins, thereby modifying their function.
Synonyms
Serine/threonine-protein kinase LMTK3; Lemur tyrosine kinase 3; LMTK3; KIAA1883; TYKLM3
Gene Name
LMTK3
Gene ID
114783
UniProt
Q96Q04
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human LMTK3 recombinant protein (Position: S1317-D1382) .
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels inly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804) . Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons.
References & Citations
1. Hanks, S.K. and Quinn, A.M. 1991. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol. 200: 38-62. 2. Nagase, T., Kikuno, R. and Ohara, O. 2001. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. DNA Res. 8: 179-187.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Lemur tyrosine kinase 3
Subcellular Location
Golgi apparatus membrane. Membrane. Single-pass membrane protein. Axon. Dendrite.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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