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Anti-Glycophorin A/GYPA Antibody Picoband® Fluoro488 Conjugated

Selected Variant

A02184-2-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Glycophorin A (MNS blood group), also known as GYPA, is a protein which in humans is encoded by the GYPAgene. It is mapped to 4q31.21. Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.

Synonyms

Glycophorin-A; MN sialoglycoprotein; PAS-2; Sialoglycoprotein alpha; CD235a; GYPA; GPA

Gene Name

GYPA

Gene ID

2993

UniProt

P02724

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Glycophorin A/GYPA.

Clonality

Polyclonal

Tissue Specificity

Renal medulla and colon. Predominantly in the inner medulla. Expressed in basal layer of epidermal keratinocytes.

Applications

Flow Cytometry

Field of Research

Cancer, Channels, Metabolism, Plasma Membrane, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175) ; binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV) .

References & Citations

1. Ko, W.-Y., Kaercher, K. A., Giombini, E., Marcatili, P., Froment, A., Ibrahim, M., Lema, G., Nyambo, T. B., Omar, S. A., Wambebe, C., Ranciaro, A., Hirbo, J. B., Tishkoff, S. A. Effects of natural selection and gene conversion on the evolution of human glycophorins coding for MNS blood polymorphisms in malaria-endemic African populations. Am. J. Hum. Genet. 88: 741-754, 2011. 2. Cooling, L. Blood groups in infection and host susceptibility. Clin. Microbiol. Rev. 28: 801-870, 2015.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

31568 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Glycophorin A (MNS blood group)

Subcellular Location

Cell membrane. Single-pass type I membrane protein.

Protein Name

Aquaporin-3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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