Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Cytochrome p450 2C19/CYP2C19 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Cytochrome P450 2C19 (abbreviated CYP2C19) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Synonyms

Cytochrome P450 2C19; (R) -limonene 6-monooxygenase; (S) -limonene 6-monooxygenase; S) -limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase; CYP2C19

Gene Name

CYP2C19

Gene ID

1557

UniProt

P33261

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Cytochrome p450 2C19/CYP2C19.

Clonality

Polyclonal

Tissue Specificity

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Applications

Flow Cytometry

Field of Research

Cancer, Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Redox Metabolism, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.

References & Citations

1. Entrez Gene: CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19. 2. Fleming I (October 2014) . The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease. Pharmacological Reviews. 66 (4) : 1106–40.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

204747 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Cytochrome P450 family 2 subfamily C member 19

Subcellular Location

Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Protein Name

Periplakin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

Recombinant Invertebrate iridescent virus 3 Putative membrane protein 047R (IIV3-047R), partial
MBS7074046 Inquire

Recombinant Invertebrate iridescent virus 3 Putative membrane protein 047R (IIV3-047R), partial

Sign In for Pricing
View Details
Progesterone Receptor (PGR) (NM_000926) Human Tagged ORF Clone
RG221303 10 µg

Progesterone Receptor (PGR) (NM_000926) Human Tagged ORF Clone

Sign In for Pricing
View Details
Magic™ Antibody Discovery - Human Fc gamma RIIIB/CD16-2 (17-200) Membrane Protein, PaRoom Temperatureial, -His tag
MP1430F Each

Magic™ Antibody Discovery - Human Fc gamma RIIIB/CD16-2 (17-200) Membrane Protein, PaRoom Temperatureial, -His tag

Sign In for Pricing
View Details
Tie-2 phospho-Tyr992 Rabbit Polyclonal Antibody
E53P01703 100 µL

Tie-2 phospho-Tyr992 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
DL-Dithiothreitol
GPC9427-U 10 g

DL-Dithiothreitol

Sign In for Pricing
View Details
Lentiviral mouse Stap2 shRNA (UAS) - Lentiviral mouse Stap2 shRNA (UAS, RFP) plasmid
GTR15175333 1 Vial

Lentiviral mouse Stap2 shRNA (UAS) - Lentiviral mouse Stap2 shRNA (UAS, RFP) plasmid

Sign In for Pricing
View Details