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Anti-CRB1 Antibody Picoband®

Boster Bio Anti-CRB1 Antibody Picoband® catalog # A01499-1. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Crumbs homolog 1 is a protein that in humans is encoded by the CRB1 gene. This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.

Synonyms

Protein crumbs homolog 1; CRB1

Gene Name

CRB1

Gene ID

23418

UniProt

P82279

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human CRB1, which shares 87.9% and 84.8% amino acid (aa) sequence identity with mouse and rat CRB1, respectively.

Clonality

Polyclonal

Tissue Specificity

Preferential expression in retina, also expressed in brain, testis, fetal brain and fetal eye.

Applications

Flow Cytometry, IHC, WB

Field of Research

Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling, Kinases/Phosphatases, Mediator Complex, Transcription

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.

References & Citations

1. Entrez Gene: CRB1 crumbs homolog 1 (Drosophila) . 2. den Hollander, A. I., Davis, J., van der Velde-Visser, S. D., Zonneveld, M. N., Pierrottet, C. O., Koenekoop, R. K., Kellner, U., van den Born, L. I., Heckenlively, J. R., Hoyng, C. B., Handford, P. A., Roepman, R., Cremers, F. P. M. CRB1 mutation spectrum in inherited retinal dystrophies. Hum. Mutat. 24: 355-369, 2004.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

75679 MW

Observed Molecular Weight

154 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Crumbs 1, cell polarity complex component

Subcellular Location

Apical cell membrane. Single-pass type I membrane protein. Secreted.

Protein Name

ATP-binding cassette sub-family G member 8

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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