Anti-Mint3/APBA3 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Amyloid beta A4 precursor protein-binding family A member 3 is a protein that in humans is encoded by the APBA3 gene. It is mapped to 19p13.3. The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.
Synonyms
Amyloid-beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3; Mint-3; APBA3; MINT3; X11L2
Gene Name
APBA3
Gene ID
9546
UniProt
O96018
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Mint3/APBA3 recombinant protein (Position: Q62-E544) .
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues examined with lower levels in brain and testis.
Applications
Flow Cytometry
Field of Research
Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
References & Citations
1. Entrez Gene: APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2) . 2. Biederer T, Cao X, Südhof TC, Liu X (Sep 2002) . Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms. J. Neurosci. 22 (17) : 7340–51. 3. Tanahashi H, Tabira T (Apr 1999) . X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein. Biochem Biophys Res Commun. 255 (3) : 663–7.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
108320 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Amyloid beta precursor protein binding family A member 3
Subcellular Location
Perinuclear region.
Protein Name
Gamma-aminobutyric acid type B receptor subunit 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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