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Anti-SMARCAD1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 is a protein that in humans is encoded by the SMARCAD1 gene. It is mapped to 4q22.3. This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Synonyms

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1; ATP-dependent helicase 1; hHEL1; SMARCAD1; KIAA1122

Gene Name

SMARCAD1

Gene ID

56916

UniProt

Q9H4L7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SMARCAD1 recombinant protein (Position: D827-T1002) .

Clonality

Polyclonal

Tissue Specificity

Isoform 1 is expressed ubiquitously. Isoform 3 is expressed mainly in skin, fibroblasts, keratinocytes and esophagus.

Applications

Flow Cytometry

Field of Research

Chromatin Remodeling, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by ing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing.

References & Citations

1. Nousbeck, J., Burger, B., Fuchs-Telem, D., Pavlovsky, M., Fenig, S., Sarig, O., Itin, P., Sprecher, E. A mutation in a skin-specific isoform of SMARCAD1 causes autosomal-dominant adermatoglyphia. Am. J. Hum. Genet. 89: 302-307, 2011. 2. Nousbeck, J., Sarig, O., Magal, L., Warschauer, E., Burger, B., Itin, P., Sprecher, E. Mutations in SMARCAD1 cause autosomal dominant adermatoglyphia and perturb the expression of epidermal differentiation-associated genes. Brit. J. Derm. 171: 1521-1524, 2014. 3. Okazaki, N., Ikeda, S., Ohara, R., Shimada, K., Yanagawa, T., Nagase, T., Ohara, O., Koga, H. The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS. J. Molec. Biol. 382: 257-265, 2008.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

80420 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1

Subcellular Location

Nucleus. Chromosome.

Protein Name

Long-chain-fatty-acid--CoA ligase 3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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