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Anti-CCR2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the CCR2 gene. It is mapped to 3p21.31. The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection.

Synonyms

C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD192; CCR2; CMKBR2

Gene Name

CCR2

Gene ID

729230

UniProt

P41597

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human CCR2 recombinant protein (Position: M1-F125) .

Clonality

Polyclonal

Tissue Specificity

Expressed by monocytes and IL2-activated NK cells.

Applications

Flow Cytometry

Field of Research

Atherosclerosis, Cancer, Cardiovascular, Chemokines, G Protein Signaling, Host-Virus Interaction, Immunology, Innate Immunity, Interspecies Interaction, Macrophage/Inflammation, Microbiology, Nuclear Signaling, Signal Transduction, Signaling Pathway, Vascular Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for the CCL2, CCL7 and CCL13 chemokines. Receptor for the beta-defensin DEFB106A/DEFB106B. Transduces a signal by increasing intracellular calcium ion levels. Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable) . (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

References & Citations

1. Abbadie, C., Lindia, J. A., Cumiskey, A. M., Peterson, L. B., Mudgett, J. S., Bayne, E. K., DeMartino, J. A., MacIntyre, D. E., Forrest, M. J. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc. Nat. Acad. Sci. 100: 7947-7952, 2003. 2. Peters, W., Dupuis, M., Charo, I. F. A mechanism for the impaired IFN-gamma production in C-C chemokine receptor 2 (CCR2) knockout mice: role of CCR2 in linking the innate and adaptive immune responses. J. Immun. 165: 7072-7077, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

C-C motif chemokine receptor 2

Subcellular Location

Cell membrane. Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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