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Anti-EDNRB Antibody Picoband® (monoclonal, 15C3) Fluoro488 Conjugated

Product Specifications

Background

Endothelin receptor type B, also known as ETB is a protein that in humans is encoded by the EDNRB gene. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms

Endothelin receptor type B; ET-B; ET-BR; Endothelin receptor non-selective type; EDNRB; ETRB

Gene Name

EDNRB

Gene ID

1910

UniProt

P24530

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human EDNRB, different from the related mouse and rat sequences by one amino acid.

Clonality

Monoclonal

Clone

Clone: 15C3

Tissue Specificity

Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.

Applications

Flow Cytometry

Field of Research

G Protein Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

References & Citations

1.Entrez Gene: EDNRB endothelin receptor type B. 2.Cyr C, Huebner K, Druck T, Kris R (November 1991) . Cloning and chromosomal localization of a human endothelin ETA receptor. Biochem. Biophys. Res. Commun. 181 (1) : 184–90.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Endothelin receptor type B

Subcellular Location

Cell membrane. Multi-pass membrane protein.

Protein Name

Heat shock protein family A (Hsp70) member 8

Isotype

Mouse IgG2b

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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