Anti-HE4/Wfdc2 Antibody Fluoro488 Conjugated
Product Specifications
Background
WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4), is a protein that in humans is encoded by the WFDC2 gene. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
Synonyms
WAP four-disulfide core domain protein 2; Epididymal secretory protein 4; RE4; Wfdc2
Gene Name
Wfdc2
Gene ID
286888
UniProt
Q8CHN3
Host
Rabbit
Reactivity
Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived rat HE4 recombinant protein (Position: E31-F168) .
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cell Type Markers, Tags & Cell Markers, Tumor Associated
Purification
Immunogen affinity purified.
Form
Liquid
Function
Broad range protease inhibitor. .
References & Citations
1. Entrez Gene: WFDC2 WAP four-disulfide core domain 2. 2. Hellström I, Raycraft J, Hayden-Ledbetter M, Ledbetter JA, Schummer M, McIntosh M, Drescher C, Urban N, Hellström KE (2003-07-01) . The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma. Cancer Research63 (13) : 3695–3700. 3. Molina R, Escudero JM, Augé JM, Filella X, Foj L, Torné A, Lejarcegui J, Pahisa J (2011) . HE4 a novel tumour marker for ovarian cancer: Comparison with CA 125 and ROMA algorithm in patients with gynaecological diseases. Tumor Biology 32 (6) : 1087–95.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
WAP four-disulfide core domain 2
Subcellular Location
Secreted .
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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