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Anti-SF3B4 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene. This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts ly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds ly to pre-mRNA.

Synonyms

Splicing factor 3B subunit 4; Pre-mRNA-splicing factor SF3b 49 kDa subunit; Spliceosome-associated protein 49; SAP 49; SF3B4; SAP49

Gene Name

SF3B4

Gene ID

10262

UniProt

Q15427

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human SF3B4, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Mostly expressed in brain and liver.

Applications

Flow Cytometry

Field of Research

DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing, Splicing

Purification

Immunogen affinity purified.

Form

Liquid

Function

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

References & Citations

1. Entrez Gene: SF3B4 splicing factor 3b, subunit 4, 49kDa. 2. Champion-Arnaud P, Reed R (Aug 1994) . The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. Genes & Development. 8 (16) : 1974–83.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

26056 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Splicing factor 3b subunit 4

Subcellular Location

Nucleus.

Protein Name

AP-2 complex subunit mu

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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