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Anti-Pyrophosphatase 1/PPA1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

PPA1 is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. By radiation hybrid analysis, the PPA1 gene is mapped to chromosome 10q21.3.

Synonyms

Inorganic pyrophosphatase; Pyrophosphate phospho-hydrolase; Ppase; PPA1; IOPPP; PP

Gene Name

PPA1

Gene ID

5464

UniProt

Q15181

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Pyrophosphatase 1/PPA1 recombinant protein (Position: E7-N236) .

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously.

Applications

Flow Cytometry

Field of Research

Cancer, Cofactors, Vitamins/Minerals, Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity) . May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. .

References & Citations

1. Curbo, S., Lagier-Tourenne, C., Carrozzo, R., Palenzuela, L., Lucioli, S., Hirano, M., Santorelli, F., Arenas, J., Karlsson, A., Johansson, M. Human mitochondrial pyrophosphatase: cDNA cloning and analysis of the gene in patients with mtDNA depletion syndromes. Genomics 87: 410-416, 2006. 2. Fairchild, T. A., Patejunas, G. Cloning and expression profile of human inorganic pyrophosphatase. Biochim. Biophys. Acta 1447: 133-136, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

51200 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Pyrophosphatase (inorganic) 1

Subcellular Location

Cytoplasm.

Protein Name

BAG family molecular chaperone regulator 5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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