Anti-POMT2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Protein O-mannosyl-transferase 2 is an enzyme that in humans is encoded by the POMT2 gene. This gene is mapped to chromosome 14q24.3. The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT1 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) .
Synonyms
Protein O-mannosyl-transferase 2; Dolichyl-phosphate-mannose--protein mannosyltransferase 2; POMT2
Gene Name
POMT2
Gene ID
29954
UniProt
Q9UKY4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human POMT2, which shares 61.9% amino acid (aa) sequence identity with both mouse and rat POMT2.
Clonality
Polyclonal
Tissue Specificity
Highly expressed in testis; detected at low levels in most tissues.
Applications
Flow Cytometry
Field of Research
Organelles, Subcellular Markers, Tags & Cell Markers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.
References & Citations
1. Biancheri, R., Falace, A., Tessa, A., Pedemonte, M., Scapolan, S., Cassandrini, D., Aiello, C., Rossi, A., Broda, P., Zara, F., Santorelli, F. M., Minetti, C., Bruno, C. POMT2 gene mutation in limb-girdle muscular dystrophy with inflammatory changes. Biochem. Biophys. Res. Commun. 363: 1033-1037, 2007. 2. Mercuri, E., D'Amico, A., Tessa, A., Berardinelli, A., Pane, M., Messina, S., van Reeuwijk, J., Bertini, E., Muntoni, F., Santorelli, F. M. POMT2 mutation in a patient with 'MEB-like' phenotype. Neuromusc. Disord. 16: 446-448, 2006.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
35883 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Protein O-mannosyltransferase 2
Subcellular Location
Endoplasmic reticulum membrane. Multi-pass membrane protein
Protein Name
Annexin A4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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