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Anti-EGFL6 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

EGFL6 is a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors.

Synonyms

Epidermal growth factor-like protein 6; EGF-like protein 6; MAM and EGF domains-containing gene protein; EGFL6; MAEG; PP648; UNQ281/PRO320

Gene Name

EGFL6

Gene ID

25975

UniProt

Q8IUX8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human EGFL6 recombinant protein (Position: K354-D535) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

Flow Cytometry

Field of Research

Growth Factors/Hormones, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) .

References & Citations

1. Buchner, G., Orfanelli, U., Quaderi, N., Bassi, M. T., Andolfi, G., Ballabio, A., Franco, B. Identification of a new EGF-repeat-containing gene from human Xp22: a candidate for developmental disorders. Genomics 65: 16-23, 2000. 2. Yeung, G., Mulero, J. J., Berntsen, R. P., Loeb, D. B., Drmanac, R., Ford, J. E. Cloning of a novel epidermal growth factor repeat containing gene EGFL6: expressed in tumor and fetal tissues. Genomics 62: 304-307, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

EGF like domain multiple 6

Subcellular Location

Basement membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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