Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-CPAMD8 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

CPAMD8 belongs to the complement component-3 (C3; 120700) /alpha-2-macroglobulin (A2M; 103950) family of proteins, which are involved in innate immunity and damage control. The encoded protein is membrane-associated and proteolytically processed to generate two chains. Mutations in this gene cause a form of anterior segment dysgenesis, a developmental disorder of the eye. By genomic sequence analysis, the CPAMD8 gene is mapped to chromosome 19p13.3-p13.2.

Synonyms

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; CPAMD8; KIAA1283

Gene Name

CPAMD8

Gene ID

27151

UniProt

Q8IZJ3

Host

Rabbit

Reactivity

Human, Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human CPAMD8 recombinant protein (Position: R58-D234) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.

Applications

Flow Cytometry

Field of Research

Complement, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Form

Liquid

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

References & Citations

1. Cheong, S.-S., Hentschel, L., Davidson, A. E., Gerrelli, D., Davie, R., Rizzo, R., Pontikos, N., Plagnol, V., Moore, A. T., Sowden, J. C., Michaelides, M., Snead, M., Tuft, S. J., Hardcastle, A. J. Mutations in CPAMD8 cause a unique form of autosomal-recessive anterior segment dysgenesis. Am. J. Hum. Genet. 99: 1338-1352, 2016. 2. Li, Z.-F., Wu, X., Engvall, E. Identification and characterization of CPAMD8, a novel member of the complement 3/alpha-2-macroglobulin family with a C-terminal Kazal domain. Genomics 83: 1083-1093, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

C3 and PZP like, alpha-2-macroglobulin domain containing 8

Subcellular Location

Secreted. Cell membrane. Peripheral membrane protein. Extracellular side.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

TSNARE1 (NM_145003) Human Untagged Clone
SC310301 10 µg

TSNARE1 (NM_145003) Human Untagged Clone

Ask
View Details
Serum Amyloid A (SAA1) Mouse Monoclonal Antibody [Clone ID: OTI6C7]
CF814037 100 µg

Serum Amyloid A (SAA1) Mouse Monoclonal Antibody [Clone ID: OTI6C7]

Ask
View Details
Mouse Monoclonal LOX-1/OLR1 Antibody (331212) [Alexa Fluor 532]
FAB1798X 0.1 mL

Mouse Monoclonal LOX-1/OLR1 Antibody (331212) [Alexa Fluor 532]

Ask
View Details
Bovine CAPS ELISA Kit
EF011188 96 Tests

Bovine CAPS ELISA Kit

Ask
View Details
Phospho-CARM1 (Ser228) Polyclonal Antibody, APC Conjugated
bs-5285R-APC 100 µL

Phospho-CARM1 (Ser228) Polyclonal Antibody, APC Conjugated

Ask
View Details
Lentiviral human EMILIN2 sgRNA gene knockout kit - Lentiviral human EMILIN2 sgRNA gene knockout kit (100)
GTR15362989 1 Vial

Lentiviral human EMILIN2 sgRNA gene knockout kit - Lentiviral human EMILIN2 sgRNA gene knockout kit (100)

Ask
View Details