Anti-NFIA Antibody Picoband® (monoclonal, 16H11) Fluoro488 Conjugated
Selected Variant
M03531-Fluoro488
Size: 100 µg/Vial
Product Specifications
Background
Nuclear factor 1 A-type?is a?protein?that in?humans?is encoded?by the?NFIA?gene. Nuclear factor I (NFI) proteins constitute a family of dimericDNA-binding proteins?with similar, and possibly identical, DNA-binding specificity. They function as cellular?transcription factors?and as replication factors for?adenovirus?DNA replication. Diversity in this protein family is generated by multiple?genes, differential?splicing, and heterodimerization.
Synonyms
Nuclear factor 1 A-type; NF1-A; Nuclear factor 1/A; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/A; NF-I/A; NFI-A; TGGCA-binding protein; NFIA; KIAA1439
Gene Name
NFIA
Gene ID
4774
UniProt
Q12857
Host
Mouse
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human NFIA, different from the related mouse sequence by one amino acid, and identical to the related rat sequence.
Clonality
Monoclonal
Clone
Clone: 16H11
Tissue Specificity
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines.
Applications
Flow Cytometry
Field of Research
Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
References & Citations
1.Leahy P, Crawford DR, Grossman G, et al. (1999) . CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription.. J. Biol. Chem. 274 (13) : 8813–22. Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995) . Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. Genomics 28 (1) : 66–73.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Nuclear factor I A
Subcellular Location
Nucleus
Isotype
Mouse IgG2b
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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