Anti-Galectin 3/LGALS3 Antibody Picoband® (monoclonal, 12B12) Fluoro647 Conjugated
Product Specifications
Background
SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
Synonyms
Galectin-3; Gal-3; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen; LGALS3; MAC2
Gene Name
LGALS3
Gene ID
3958
UniProt
P17931
Host
Mouse
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Galectin 3 recombinant protein (Position: K139-I250) . Human Galectin 3 shares 88% and 84% amino acid (aa) sequence identity with mouse and rat Galectin 3, respectively.
Clonality
Monoclonal
Clone
Clone: 12B12
Tissue Specificity
A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
Applications
Flow Cytometry
Field of Research
Cancer, Cell Cycle, Cell Division, Oncoproteins, Tumor Biomarkers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity) . In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.
References & Citations
1. Dumic J, Dabelic S, Flögel M. (2006) . Galectin-3: an open-ended story.. BBA General Subjects 1760 (4) : 616–635. 2. Liu F, Patterson RJ, Wang JL. (2002) . Intracellular function of galectins.. BBA General Subjects 1572 (2-3) : 263–273. 3. Cooper D. (2002) . Galectinomics: finding themes in complexity.. BBA General Subjects 1572 (2-3) : 209–231. 4. Raimond J, Zimonjic DB, Mignon C, et al. (1997) . Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at region 14q21—22.. Mamm. Genome 8 (9) : 706–707.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Lectin, galactoside-binding, soluble, 3
Subcellular Location
Secreted. Nucleus. Cytoplasm.
Isotype
Mouse IgG2a
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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