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Anti-RHOB Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene. This gene is mapped to 2p24.1. It is a member of the Rho GTP-binding protein family. And RHOB has been shown to interact with CIT, ARHGEF3, ARHGDIG and RHPN2. RHOB plays a negative role in tumorigenesis as deletion causes tumor formation. Also, it serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis.

Synonyms

Rho-related GTP-binding protein RhoB; Rho cDNA clone 6; h6; RHOB; ARH6; ARHB

Gene Name

RHOB

Gene ID

388

UniProt

P62745

Host

Rabbit

Reactivity

Human, Monkey, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human RHOB, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

Applications

Flow Cytometry

Field of Research

Small G Proteins, Vesicle Transport

Purification

Immunogen affinity purified.

Form

Liquid

Function

Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

References & Citations

1. Cannizzaro, L. A., Madaule, P., Hecht, F., Axel, R., Croce, C. M., Huebner, K. Chromosome localization of human ARH genes, a ras-related gene family. Genomics 6: 197-203, 1990. 2. Chardin, P., Madaule, P., Tavitian, A. Coding sequence of human rho cDNAs clone 6 and clone 9. Nucleic Acid Res. 16: 2717 only, 1988. 3. Madaule, P., Axel, R. A novel ras-related gene family. Cell 41: 31-40, 1985.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

105324 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Ras homolog family member B

Subcellular Location

Cell membrane, Lipid-anchor, Late endosome membrane, Nucleus, Cleavage furrow.

Protein Name

Lysosomal alpha-glucosidase

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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